When Is a Skin Cancer a Cancer: The Histopathologist’s View
نویسندگان
چکیده
Non-melanoma skin cancers typically develop on a background of “sun damage” characterized by solar elastosis as well as varying degrees of epithelial atypia and architectural disorder. Molecular data from both skin and other organs suggest that these observations are manifestations of fi eld cancerization. The presence of widespread actinic keratoses (AKs) and the high incidence of multiple primary cutaneous cancers in patients with severe sun damage are the most obvious manifestations of fi eld cancerization in the skin. The fi nding of cutaneous squamous cell carcinomas (SCCs) arising within actinic keratoses (Fig. 2.1) is evidence of multistage carcinogenesis where progressive genetic aberrations eventually result in an invasive cancer arising on a background of fi eld cancerization. This chapter examines the concept of fi eld cancerization from the dermatopathologist’s point of view as well as histologic and When Is a Skin Cancer a Cancer: The Histopathologist’s View
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